Across TCGA cell cohorts, SREBF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,701 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SREBF2-associated GO terms across cancer lineages are Secondary alcohol biosynthetic process, Zymosterol metabolic process, and Zymosterol biosynthetic process. Each is linked with SREBF2 in more than 16 cancer types. Because this analysis shows association rather than direction, both SREBF2-to-partner and partner-to-SREBF2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SREBF2→partner) and Y-score (partner→SREBF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Secondary alcohol biosynthetic process →	+0.203	+1.573	<.001	<.001	3	17
URINARY_TRACT	Zymosterol metabolic process →	+0.206	+1.105	<.001	<.001	3	17
URINARY_TRACT	Zymosterol biosynthetic process →	+0.206	+1.105	<.001	<.001	3	17
LUNG_SCLC	Cholesterol biosynthetic process →	+0.203	+1.573	<.001	<.001	3	17
PANCREAS	Negative regulation of chromosome condensation →	+0.167	+1.050	<.001	<.001	3	16
URINARY_TRACT	Isopentenyl diphosphate biosynthetic process →	+0.218	+1.039	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,701 associations by consensus.

Exploration

SREBF2 survival (RNA) · tumor vs normal (RNA) · all SREBF2 data types