SREBF2

mutation — cross-omics
Cross-omicsMUTATION → RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, SREBF2 mutation is significantly associated with the RNA expression of many other genes, with 123 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SREBF2-associated genes across cancer lineages are ITIH6, FAM160A1, and INSM2. Each is linked with SREBF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SREBF2-to-partner and partner-to-SREBF2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SREBF2→partner) and Y-score (partner→SREBF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BLOOD_LeukemiaITIH6 →+0.020+4.169<.001<.00132
BLOOD_LeukemiaFAM160A1 →+0.230+3.684.005.00532
BLOOD_LeukemiaINSM2 →+0.178+4.354<.001<.00132
UPPER_AERODIGESTIVE_TRACTGFRA4 →+0.013+4.736<.001.00932
UPPER_AERODIGESTIVE_TRACTGUCA2A →+0.065+4.736<.001.00932
URINARY_TRACTPRAMEF25 →+0.013+5.087<.001.00431
Each partner links to its Q-omics profile. Showing the 6 strongest of 123 associations by consensus.

Exploration