SRD5A3

Across TCGA pan-cancer cohorts, SRD5A3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SRD5A3 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SRD5A3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SRD5A3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where SRD5A3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.738	0.943	.002	16	view →
HNSC	DFS	Tertile	All	0.414	0.947	.008	14	view →
LUAD	DFS	Tertile	All	0.553	0.931	.007	13	view →
PDAC	DFS	Quartile	All	0.394	0.672	.019	9	view →
UCEC	OS	Quartile	All	1.000	0.887	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SRD5A3–CCRCC (OS)

Open the CCRCC breakdown →