SRD5A3

Across TCGA patient cohorts, SRD5A3 mutation is significantly associated with the RNA expression of many other genes, with 1,229 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRD5A3-associated genes across cancer lineages are TMOD4, LINC02438, and RNA5SP423. Each is linked with SRD5A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRD5A3-to-partner and partner-to-SRD5A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMOD4 grouped by SRD5A3-low versus SRD5A3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRD5A3→partner) and Y-score (partner→SRD5A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	TMOD4 →	+0.022	+6.632	<.001	<.001	3	2
UCEC	LINC02438 →	+0.813	+3.609	<.001	.001	3	2
UCEC	RNA5SP423 →	+0.928	+2.132	<.001	.008	3	2
BLCA	LINC00459 →	+0.221	+5.018	<.001	.004	3	1
BLCA	OFD1P3Y →	+0.128	+5.018	<.001	.004	3	1
BLCA	LINC01049 →	+0.529	+4.238	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,229 associations by consensus.

TMOD4 by SRD5A3 expression — BLCA

Explore this box plot interactively →