SRD5A3

Across TCGA patient cohorts, SRD5A3 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRD5A3-associated genes across cancer lineages are 14-3-3_beta, eIF4G, and FoxM1. Each is linked with SRD5A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRD5A3-to-partner and partner-to-SRD5A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by SRD5A3-low versus SRD5A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRD5A3→partner) and Y-score (partner→SRD5A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.115	-3.143	.014	.018	3	1
UCEC	eIF4G →	+0.302	+3.321	.037	.010	3	1
UCEC	FoxM1 →	+0.353	+2.584	.003	.011	3	1
UCEC	Ku80 →	+0.228	+1.887	.038	.031	3	1
UCEC	MSH2 →	-0.217	-2.312	.043	.034	3	1
UCEC	Notch1 →	+0.184	+3.013	.005	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

14-3-3_beta by SRD5A3 expression — UCEC

Explore this box plot interactively →