SRD5A3-AS1

Across TCGA pan-cancer cohorts, SRD5A3-AS1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SRD5A3-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SRD5A3-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SRD5A3-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UCS show a favorable association.

KIRC, UVM, and STAD are the cancer types where SRD5A3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.539	0.712	<.001	137	view →
UVM	DFS	Quartile	II,III,IV	0.289	0.788	.001	74	view →
STAD	DFS	Tertile	II,III,IV	0.518	0.668	.008	38	view →
SKCM	DFS	Median	All	0.670	0.570	.002	35	view →
KIRP	DFS	Quartile	All	0.722	0.949	<.001	32	view →
LIHC	DFS	Tertile	All	0.415	0.592	<.001	31	view →
UCS	DFS	Median	IV	0.909	0.416	.008	22	view →
HNSC	DFS	Median	All	0.738	0.652	.015	21	view →
LUAD	OS	Tertile	III,IV	0.705	0.257	.002	17	view →
LAML	DFS	Quartile	All	0.732	0.381	.012	16	view →
PCPG	DFS	Tertile	All	0.613	0.900	.011	16	view →
UCEC	OS	Median	All	0.827	0.595	.005	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SRD5A3-AS1–KIRC (DFS)

Open the KIRC breakdown →