SRD5A2

Across TCGA pan-cancer cohorts, SRD5A2 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SRD5A2 data layer compared with 20 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SRD5A2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SRD5A2 expression acts as an unfavorable survival marker.

HNSC, UCEC, and PRAD are the cancer types where SRD5A2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.138	0.710	.001	24	view →
UCEC	OS	Median	IV	0.066	0.755	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SRD5A2–HNSC (OS)

Open the HNSC breakdown →