SRD5A2

Across TCGA patient cohorts, SRD5A2 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,109 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible SRD5A2-associated GO terms across cancer lineages are Cytoskeleton-dependent intracellular transport, Endoplasmic reticulum unfolded protein response, and Endoplasmic reticulum to Golgi vesicle-mediated transport. Each is linked with SRD5A2 in more than 15 cancer types. Because this analysis shows association rather than direction, both SRD5A2-to-partner and partner-to-SRD5A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoskeleton-dependent intracellular transport grouped by SRD5A2-low versus SRD5A2-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRD5A2→partner) and Y-score (partner→SRD5A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Cytoskeleton-dependent intracellular transport →	+0.062	+0.219	<.001	<.001	3	16
ESCA	Endoplasmic reticulum unfolded protein response →	+0.087	+0.268	<.001	.001	3	15
STAD	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.082	+0.118	<.001	<.001	3	15
STAD	Vesicle budding from membrane →	+0.081	+0.105	<.001	<.001	3	15
SCLC	Golgi organization →	+0.074	+0.378	<.001	.002	3	15
ESCA	Cellular response to unfolded protein →	+0.084	+0.178	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,109 associations by consensus.

Cytoskeleton-dependent intracellular transport by SRD5A2 expression — ESCA

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