SRD5A2

Across TCGA patient cohorts, SRD5A2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRD5A2-associated genes across cancer lineages are Caspase-8, P-Cadherin, and S6_pS240_S244. Each is linked with SRD5A2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRD5A2-to-partner and partner-to-SRD5A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by SRD5A2-low versus SRD5A2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRD5A2→partner) and Y-score (partner→SRD5A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.291	-3.143	.035	.018	3	1
UCEC	P-Cadherin →	-0.196	-3.156	.013	.020	2	1
UCEC	S6_pS240_S244 →	+0.492	+3.169	.027	.020	2	1
UCEC	EGFR_pY1068 →	-0.361	-3.169	.008	.020	1	1
UCEC	FASN →	+0.703	+3.169	.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Caspase-8 by SRD5A2 expression — UCEC

Explore this box plot interactively →