SRD5A1

Across TCGA cell cohorts, SRD5A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,759 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible SRD5A1-associated GO terms across cancer lineages are Response to serotonin, Cellular response to serotonin, and Thalamus development. Each is linked with SRD5A1 in more than 16 cancer types. Because this analysis shows association rather than direction, both SRD5A1-to-partner and partner-to-SRD5A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to serotonin grouped by SRD5A1-low versus SRD5A1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SRD5A1→partner) and Y-score (partner→SRD5A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Response to serotonin →	+0.275	+1.649	<.001	<.001	3	17
URINARY_TRACT	Cellular response to serotonin →	+0.275	+1.649	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Thalamus development →	+0.232	+1.535	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Response to fungicide →	+0.139	+1.201	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Response to stilbenoid →	+0.292	+1.524	<.001	<.001	3	14
URINARY_TRACT	Cellular response to testosterone stimulus →	+0.252	+1.322	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,759 associations by consensus.

Response to serotonin by SRD5A1 expression — URINARY_TRACT

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