SRCIN1

Across TCGA patient cohorts, SRCIN1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRCIN1-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and GATA6. Each is linked with SRCIN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SRCIN1-to-partner and partner-to-SRCIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SRCIN1-low versus SRCIN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRCIN1→partner) and Y-score (partner→SRCIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.553	+2.000	.007	.029	3	3
UCEC	Cyclin-B1 →	+0.475	+2.115	.014	.017	3	3
COAD	GATA6 →	-0.274	-3.321	.003	.010	3	2
COAD	PREX1 →	+0.306	+3.484	.001	.002	3	2
COAD	Rab25 →	-0.445	-3.450	<.001	.005	3	2
UCEC	Annexin-1 →	+0.514	+1.827	.004	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Caspase-7-cleavedD198 by SRCIN1 expression — UCEC

Explore this box plot interactively →