SRCIN1

Across TCGA cell cohorts, SRCIN1 mutation is significantly associated with the RNA expression of many other genes, with 693 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRCIN1-associated genes across cancer lineages are C1QA, ZMYND8, and PSMA7. Each is linked with SRCIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRCIN1-to-partner and partner-to-SRCIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QA grouped by SRCIN1-low versus SRCIN1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRCIN1→partner) and Y-score (partner→SRCIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	C1QA →	+0.051	+2.793	.002	.002	3	2
LARGE_INTESTINE	ZMYND8 →	-0.550	-2.126	.008	<.001	3	2
LARGE_INTESTINE	PSMA7 →	-0.431	-3.636	.001	<.001	3	2
LARGE_INTESTINE	PPDPF →	-0.610	-2.126	.003	<.001	3	2
LARGE_INTESTINE	RALY →	-0.389	-3.459	.006	.001	3	2
LARGE_INTESTINE	RELL2 →	-1.092	-2.126	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 693 associations by consensus.

C1QA by SRCIN1 expression — SKIN

Explore this box plot interactively →