SRCAP

Across TCGA patient cohorts, SRCAP mutation is significantly associated with the RNA expression of many other genes, with 8,138 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRCAP-associated genes across cancer lineages are RAD51, OIP5, and ASF1B. Each is linked with SRCAP in more than 5 cancer types. Because this analysis shows association rather than direction, both SRCAP-to-partner and partner-to-SRCAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by SRCAP-low versus SRCAP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRCAP→partner) and Y-score (partner→SRCAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51 →	+0.577	+1.567	<.001	<.001	3	6
UCEC	OIP5 →	+0.596	+1.466	<.001	<.001	3	6
BLCA	ASF1B →	+0.631	+2.094	.005	.003	3	6
COAD	ECT2 →	+0.669	+2.415	<.001	.003	3	6
COAD	CCNB1 →	+0.462	+2.834	.001	.001	3	6
LUAD	ADAMTS8 →	-0.825	-2.459	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,138 associations by consensus.

RAD51 by SRCAP expression — UCEC

Explore this box plot interactively →