SRCAP

Across TCGA patient cohorts, SRCAP mutation is significantly associated with the total protein of many other genes, with 87 significant associations in total. COAD shows the largest number of these associations.

The most reproducible SRCAP-associated genes across cancer lineages are ASNS, Cyclin-B1, and GAPDH. Each is linked with SRCAP in more than 3 cancer types. Because this analysis shows association rather than direction, both SRCAP-to-partner and partner-to-SRCAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SRCAP-low versus SRCAP-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRCAP→partner) and Y-score (partner→SRCAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.423	+2.222	.003	.009	3	4
BLCA	Cyclin-B1 →	+0.386	+3.169	.032	.018	3	4
COAD	GAPDH →	+0.578	+2.423	.001	.001	3	4
COAD	PCNA →	+0.241	+1.887	.007	.029	3	4
COAD	PDCD4 →	-0.309	-1.898	.043	.016	3	4
BLCA	Chk2 →	+0.238	+2.321	.006	.033	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 87 associations by consensus.

ASNS by SRCAP expression — COAD

Explore this box plot interactively →