SRCAP

Across TCGA cell cohorts, SRCAP mutation is significantly associated with the RNA expression of many other genes, with 2,493 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRCAP-associated genes across cancer lineages are KBTBD13, KDSR, and KIAA0895. Each is linked with SRCAP in more than 2 cancer types. Because this analysis shows association rather than direction, both SRCAP-to-partner and partner-to-SRCAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KBTBD13 grouped by SRCAP-low versus SRCAP-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRCAP→partner) and Y-score (partner→SRCAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KBTBD13 →	+0.019	+3.977	<.001	<.001	3	3
LARGE_INTESTINE	KDSR →	+0.922	+2.180	<.001	<.001	3	3
BLOOD_Leukemia	KIAA0895 →	+0.895	+3.614	<.001	<.001	3	3
LARGE_INTESTINE	KSR2 →	+0.331	+1.290	.002	.006	3	3
LARGE_INTESTINE	GRSF1 →	+0.506	+1.782	<.001	.002	3	3
LARGE_INTESTINE	LYG1 →	+0.963	+1.850	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,493 associations by consensus.

KBTBD13 by SRCAP expression — LUNG_SCLC

Explore this box plot interactively →