Across TCGA patient cohorts, SRC mutation is significantly associated with the RNA expression of many other genes, with 1,939 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRC-associated genes across cancer lineages are RPL21P88, MRPL40, and ZNF749. Each is linked with SRC in more than 1 cancer types. Because this analysis shows association rather than direction, both SRC-to-partner and partner-to-SRC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRC→partner) and Y-score (partner→SRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RPL21P88 →	+0.116	+3.705	<.001	.008	3	2
UCEC	MRPL40 →	+0.336	+3.387	.009	.004	3	2
UCEC	ZNF749 →	+0.544	+3.828	<.001	<.001	3	2
UCEC	CCDC7 →	+0.296	+3.592	<.001	.001	3	2
UCEC	MTATP6P21 →	+0.288	+1.867	<.001	.007	3	2
UCEC	NPLP1 →	+0.179	+1.943	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,939 associations by consensus.

Exploration

SRC survival (RNA) · tumor vs normal (RNA) · all SRC data types