Across TCGA patient cohorts, SRC mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRC-associated genes across cancer lineages are EGFR_pY1068, mTOR_pS2448, and p38-MAPK_pT180_Y182. Each is linked with SRC in more than 1 cancer types. Because this analysis shows association rather than direction, both SRC-to-partner and partner-to-SRC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRC→partner) and Y-score (partner→SRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.255	-2.906	.016	.001	3	1
UCEC	mTOR_pS2448 →	-0.129	-2.308	.041	.033	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.518	-3.169	.006	.019	3	1
UCEC	Shc_pY317 →	-0.180	-3.584	.005	.002	3	1
UCEC	STAT3_pY705 →	-0.295	-2.449	.007	.019	3	1
UCEC	VHL →	-0.879	-3.169	.002	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

SRC survival (RNA) · tumor vs normal (RNA) · all SRC data types