Across TCGA cell cohorts, SRC mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SRC-associated genes across cancer lineages are SLC32A1, APOL5, and CLDN8. Each is linked with SRC in more than 1 cancer types. Because this analysis shows association rather than direction, both SRC-to-partner and partner-to-SRC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRC→partner) and Y-score (partner→SRC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC32A1 →	+0.655	+3.901	<.001	.006	3	1
BLOOD_Leukemia	APOL5 →	+0.012	+4.060	.002	.003	3	1
BLOOD_Leukemia	CLDN8 →	+0.012	+4.234	<.001	.003	3	1
BLOOD_Leukemia	INSM2 →	+0.163	+3.769	.002	.008	3	1
BLOOD_Leukemia	LY6H →	+1.076	+3.855	.005	.007	3	1
BLOOD_Leukemia	SMIM23 →	+0.018	+4.984	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

SRC survival (RNA) · tumor vs normal (RNA) · all SRC data types