SRBD1

Across TCGA pan-cancer cohorts, SRBD1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SRBD1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SRBD1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SRBD1 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

HNSC, PDAC, and LSCC are the cancer types where SRBD1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SRBD1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.142	<.001	8	view →
PDAC	All	All	−0.206	<.001	7	view →
LSCC	All	All	+0.089	.001	3	view →
LUAD	All	All	+0.052	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SRBD1–HNSC

Open the HNSC breakdown →