SRBD1

Across TCGA patient cohorts, SRBD1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRBD1-associated genes across cancer lineages are PDCD4, eIF4E, and 4E-BP1. Each is linked with SRBD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SRBD1-to-partner and partner-to-SRBD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by SRBD1-low versus SRBD1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRBD1→partner) and Y-score (partner→SRBD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PDCD4 →	-0.621	-3.000	.004	.035	3	3
UCEC	eIF4E →	+0.197	+2.523	.006	<.001	3	3
COAD	4E-BP1 →	+0.378	+3.008	<.001	.019	2	3
COAD	C-Raf →	+0.226	+3.008	.002	.019	3	2
UCEC	FoxM1 →	+0.257	+1.807	.003	.004	3	2
UCEC	INPP4B →	-0.284	-3.906	.010	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

PDCD4 by SRBD1 expression — COAD

Explore this box plot interactively →