Across TCGA patient cohorts, SRA1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRA1-associated genes across cancer lineages are eEF2, JNK2, and Myosin-IIa_pS1943. Each is linked with SRA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRA1-to-partner and partner-to-SRA1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRA1→partner) and Y-score (partner→SRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.482	+3.000	.019	.037	3	1
UCEC	JNK2 →	+0.275	+3.000	.016	.037	3	1
UCEC	Myosin-IIa_pS1943 →	+0.252	+3.013	.035	.019	3	1
UCEC	PEA-15_pS116 →	+0.511	+3.000	.011	.037	3	1
UCEC	PCNA →	+0.362	+3.000	.003	.037	2	1
UCEC	Raptor →	-0.216	-3.000	.014	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

SRA1 survival (RNA) · tumor vs normal (RNA) · all SRA1 data types