SQSTM1P1

Across TCGA patient cohorts, SQSTM1P1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,930 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SQSTM1P1-associated GO terms across cancer lineages are Neuromuscular process, Positive regulation of double-strand break repair via homologous recombination, and Positive regulation of protein localization to nucleus. Each is linked with SQSTM1P1 in more than 6 cancer types. Because this analysis shows association rather than direction, both SQSTM1P1-to-partner and partner-to-SQSTM1P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neuromuscular process grouped by SQSTM1P1-low versus SQSTM1P1-high in UCS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SQSTM1P1→partner) and Y-score (partner→SQSTM1P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	Neuromuscular process →	+0.060	+0.324	<.001	.002	3	7
STAD	Positive regulation of double-strand break repair via homologous recombination →	+0.111	+0.044	<.001	<.001	3	6
STAD	Positive regulation of protein localization to nucleus →	+0.139	+0.039	<.001	<.001	3	6
STAD	Organic hydroxy compound biosynthetic process →	+0.079	+0.048	<.001	<.001	3	6
STAD	Regulation of miRNA metabolic process →	+0.125	+0.041	<.001	<.001	3	6
STAD	Mitotic G1/S transition checkpoint signaling →	+0.118	+0.043	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,930 associations by consensus.

Neuromuscular process by SQSTM1P1 expression — UCS

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