SQSTM1

Across TCGA pan-cancer cohorts, SQSTM1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SQSTM1 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SQSTM1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SQSTM1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, CCRCC, and GBM are the cancer types where SQSTM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	1.000	0.494	.016	20	view →
CCRCC	OS	Median	All	0.615	1.000	.001	16	view →
GBM	OS	Tertile	All	0.261	0.517	.009	10	view →
LSCC	OS	Tertile	All	0.843	0.943	.022	8	view →
HNSC	OS	Median	All	1.000	0.961	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SQSTM1–UCEC (OS)

Open the UCEC breakdown →