SQSTM1

Across TCGA patient cohorts, SQSTM1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,888 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SQSTM1-associated genes across cancer lineages are PRDX1, NMRAL2P, and PIR. Each is linked with SQSTM1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SQSTM1-to-partner and partner-to-SQSTM1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SQSTM1 versus PRDX1 in UCEC, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SQSTM1→partner) and Y-score (partner→SQSTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRDX1 →	+1.107	+0.425	<.001	<.001	3	5
LSCC	NMRAL2P →	+2.999	+0.495	<.001	<.001	3	5
UCEC	PIR →	+1.259	+0.345	<.001	.001	3	5
LSCC	TXNRD1 →	+1.393	+0.416	<.001	<.001	3	5
LSCC	EID3 →	+1.387	+0.437	<.001	<.001	3	5
LUAD	DAP3 →	+0.395	+0.432	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,888 associations by consensus.

SQSTM1 vs PRDX1 — UCEC

Explore this scatter interactively →