SQSTM1

Across TCGA cell cohorts, SQSTM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,263 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SQSTM1-associated GO terms across cancer lineages are Cellular response to osmotic stress, Viral process, and Cytoplasmic pattern recognition receptor signaling pathway. Each is linked with SQSTM1 in more than 12 cancer types. Because this analysis shows association rather than direction, both SQSTM1-to-partner and partner-to-SQSTM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to osmotic stress grouped by SQSTM1-low versus SQSTM1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SQSTM1→partner) and Y-score (partner→SQSTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Cellular response to osmotic stress →	+0.105	+1.495	.005	.001	3	12
BONE	Viral process →	+0.085	+1.429	<.001	<.001	3	12
LUNG_NSCLC_LUAD	Cytoplasmic pattern recognition receptor signaling pathway →	+0.080	+1.212	<.001	<.001	3	12
LUNG_NSCLC_LUAD	Intracellular receptor signaling pathway →	+0.053	+1.439	<.001	<.001	3	12
LIVER	Regulation of response to endoplasmic reticulum stress →	+0.078	+1.620	.002	.007	2	13
LIVER	Canonical NF-kappaB signal transduction →	+0.132	+2.035	<.001	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,263 associations by consensus.

Cellular response to osmotic stress by SQSTM1 expression — KIDNEY

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