SQOR

Across TCGA patient cohorts, SQOR mutation is significantly associated with the RNA expression of many other genes, with 2,838 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SQOR-associated genes across cancer lineages are RNU6-573P, WFDC2, and LACTB. Each is linked with SQOR in more than 2 cancer types. Because this analysis shows association rather than direction, both SQOR-to-partner and partner-to-SQOR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-573P grouped by SQOR-low versus SQOR-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SQOR→partner) and Y-score (partner→SQOR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RNU6-573P →	+0.338	+7.977	<.001	.007	3	3
UCEC	WFDC2 →	-2.001	-3.148	<.001	<.001	3	2
UCEC	LACTB →	+0.489	+2.732	<.001	.003	3	2
UCEC	ABCG2 →	-0.728	-4.247	<.001	<.001	3	2
UCEC	ITGB1BP1 →	+0.372	+3.601	.004	.001	3	2
UCEC	EMC3 →	+0.426	+2.513	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,838 associations by consensus.

RNU6-573P by SQOR expression — LGG

Explore this box plot interactively →