SQLE

Across TCGA pan-cancer cohorts, SQLE mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SQLE data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SQLE mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SQLE expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

CCRCC, LSCC, and OV are the cancer types where SQLE mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.234	1.000	.011	23	view →
LSCC	DFS	Tertile	All	0.425	1.000	.006	10	view →
OV	DFS	Median	All	0.671	0.942	.013	8	view →
HNSC	DFS	Median	III,IV	0.754	0.509	.010	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SQLE–CCRCC (DFS)

Open the CCRCC breakdown →