SPTY2D1OS

Across TCGA pan-cancer cohorts, SPTY2D1OS RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SPTY2D1OS’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SPTY2D1OS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPTY2D1OS is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

COAD, LIHC, and KIRC are the cancer types where SPTY2D1OS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPTY2D1OS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+0.574	<.001	10	view →
LIHC	All	II,III,IV	+0.487	<.001	9	view →
KIRC	All	II,III,IV	−0.215	<.001	6	view →
CHOL	All	All	+0.943	<.001	5	view →
LUSC	All	All	+0.319	<.001	5	view →
LUAD	All	All	+0.306	<.001	5	view →
KICH	All	All	−0.381	<.001	4	view →
BRCA	All	III,IV	+0.381	<.001	4	view →
THCA	All	All	−0.189	<.001	4	view →
STAD	All	All	+0.231	.026	3	view →
ESCA	All	II,III,IV	+0.490	.035	2	view →
PRAD	All	All	+0.348	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SPTY2D1OS–COAD

Open the COAD breakdown →