SPTY2D1

Across TCGA patient cohorts, SPTY2D1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTY2D1-associated genes across cancer lineages are Notch1, PAI-1, and PKC-b-II_pS660. Each is linked with SPTY2D1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPTY2D1-to-partner and partner-to-SPTY2D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SPTY2D1-low versus SPTY2D1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTY2D1→partner) and Y-score (partner→SPTY2D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.126	+2.335	.002	.002	3	3
UCEC	PAI-1 →	+0.361	+1.459	<.001	.011	3	3
UCEC	PKC-b-II_pS660 →	-0.177	-1.184	.031	.022	3	3
UCEC	ATM →	-0.545	-1.807	<.001	<.001	3	3
UCEC	FASN →	+0.292	+1.184	.012	.022	3	2
UCEC	ACC1 →	+0.246	+1.598	.023	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Notch1 by SPTY2D1 expression — UCEC

Explore this box plot interactively →