SPTY2D1

Across TCGA cell cohorts, SPTY2D1 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPTY2D1-associated genes across cancer lineages are COX6A2, RPE65, and CASQ2. Each is linked with SPTY2D1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPTY2D1-to-partner and partner-to-SPTY2D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX6A2 grouped by SPTY2D1-low versus SPTY2D1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTY2D1→partner) and Y-score (partner→SPTY2D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	COX6A2 →	+0.527	+3.256	<.001	.005	3	2
BLOOD_Leukemia	RPE65 →	+0.045	+3.475	<.001	.006	3	1
BLOOD_Leukemia	CASQ2 →	+0.056	+3.926	<.001	.003	3	1
BLOOD_Leukemia	C20orf85 →	+0.024	+3.969	<.001	.009	3	1
BLOOD_Leukemia	IL22 →	+0.025	+4.569	<.001	.003	3	1
BLOOD_Leukemia	CCDC158 →	+0.035	+3.734	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

COX6A2 by SPTY2D1 expression — LUNG_SCLC

Explore this box plot interactively →