Across TCGA pan-cancer cohorts, SPTSSB Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SPTSSB data layer compared with 24 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SPTSSB Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPTSSB expression acts as an unfavorable survival marker.

LUAD and UCEC are the cancer types where SPTSSB Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.098	0.791	<.001	18	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: SPTSSB tumor-vs-normal RNA expression · all SPTSSB data types