SPTSSA

Across TCGA patient cohorts, SPTSSA mutation is significantly associated with the RNA expression of many other genes, with 395 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTSSA-associated genes across cancer lineages are LAMTOR1, TSPAN7, and RPUSD3. Each is linked with SPTSSA in more than 1 cancer types. Because this analysis shows association rather than direction, both SPTSSA-to-partner and partner-to-SPTSSA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LAMTOR1 grouped by SPTSSA-low versus SPTSSA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTSSA→partner) and Y-score (partner→SPTSSA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LAMTOR1 →	+0.417	+3.470	.009	.003	3	1
UCEC	TSPAN7 →	-1.538	-3.448	.001	.005	3	1
UCEC	RPUSD3 →	+0.410	+3.480	.003	.002	3	1
UCEC	ATP5MC1 →	+0.651	+3.459	<.001	.005	3	1
UCEC	SNF8 →	+0.531	+3.402	.001	.004	3	1
UCEC	CLDND2 →	+0.810	+3.470	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 395 associations by consensus.

LAMTOR1 by SPTSSA expression — UCEC

Explore this box plot interactively →