SPTLC3

Across TCGA patient cohorts, SPTLC3 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTLC3-associated genes across cancer lineages are FoxM1, PKC-delta_pS664, and Caspase-7-cleavedD198. Each is linked with SPTLC3 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPTLC3-to-partner and partner-to-SPTLC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SPTLC3-low versus SPTLC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTLC3→partner) and Y-score (partner→SPTLC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.267	+2.807	.001	.002	3	4
UCEC	PKC-delta_pS664 →	-0.085	-2.321	.025	.005	3	3
UCEC	Caspase-7-cleavedD198 →	+0.764	+2.019	<.001	.001	3	3
COAD	C-Raf →	+0.188	+2.815	.019	.036	3	2
UCEC	eIF4E →	+0.164	+1.836	.013	.001	3	2
UCEC	PCNA →	+0.278	+2.115	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

FoxM1 by SPTLC3 expression — UCEC

Explore this box plot interactively →