Across TCGA pan-cancer cohorts, SPTLC1P5 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SPTLC1P5’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where SPTLC1P5 RNA is repressed in tumor relative to normal tissue. In most cancer types SPTLC1P5 is over-expressed in tumor, although a few such as LUSC and HNSC show the opposite, repressed pattern.

LUSC, KIRC, and BRCA are the cancer types where SPTLC1P5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPTLC1P5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	−0.195	<.001	6	view →
KIRC	Male	All	+0.097	.005	4	view →
BRCA	All	All	+0.061	.020	4	view →
HNSC	All	II,III,IV	−0.123	.006	3	view →
KIRP	All	All	+0.170	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: SPTLC1P5 RNA expression & survival · all SPTLC1P5 data types