SPTLC1

Across TCGA patient cohorts, SPTLC1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,471 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPTLC1-associated proteins across cancer lineages are FUBP3, CORO2A, and GOLGA1. Each is linked with SPTLC1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SPTLC1-to-partner and partner-to-SPTLC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPTLC1 versus FUBP3 in LSCC, with a Pearson correlation of 0.57.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTLC1→partner) and Y-score (partner→SPTLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FUBP3 →	+0.197	+0.504	<.001	<.001	3	6
LUAD	CORO2A →	+0.628	+0.485	<.001	<.001	3	5
OV	GOLGA1 →	+0.271	+0.453	.007	.002	3	5
OV	PSMD5 →	+0.290	+0.394	<.001	<.001	3	5
BRCA	RAD23B →	+0.313	+0.639	<.001	<.001	3	5
PDAC	PTBP3 →	+0.224	+0.246	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,471 associations by consensus.

SPTLC1 vs FUBP3 — LSCC

Explore this scatter interactively →