SPTLC1

Across TCGA patient cohorts, SPTLC1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,544 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPTLC1-associated genes across cancer lineages are ARPC5L, PNOC, and P2RY8. Each is linked with SPTLC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SPTLC1-to-partner and partner-to-SPTLC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPTLC1 versus ARPC5L in LSCC, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTLC1→partner) and Y-score (partner→SPTLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ARPC5L →	+0.430	+0.223	<.001	<.001	3	5
LSCC	PNOC →	-0.547	-0.204	<.001	<.001	3	5
LUAD	P2RY8 →	-0.757	-0.290	<.001	<.001	3	5
HNSC	ESRP2 →	+0.574	+0.158	.002	.008	3	4
HNSC	ICAM2 →	-0.790	-0.197	.003	.003	3	4
HNSC	IL10RA →	-0.724	-0.166	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,544 associations by consensus.

SPTLC1 vs ARPC5L — LSCC

Explore this scatter interactively →