SPTLC1

Across TCGA patient cohorts, SPTLC1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTLC1-associated genes across cancer lineages are ER-alpha_pS118, ATM, and eEF2. Each is linked with SPTLC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPTLC1-to-partner and partner-to-SPTLC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha_pS118 grouped by SPTLC1-low versus SPTLC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTLC1→partner) and Y-score (partner→SPTLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha_pS118 →	+0.435	+2.820	.012	.035	3	2
UCEC	ATM →	-0.627	-3.584	.004	.002	3	2
UCEC	eEF2 →	+0.443	+3.169	.010	.019	3	1
UCEC	GATA6 →	-0.175	-3.169	.023	.019	3	1
UCEC	Heregulin →	-0.133	-3.156	.025	.018	3	1
UCEC	INPP4B →	-0.362	-3.321	.020	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ER-alpha_pS118 by SPTLC1 expression — UCEC

Explore this box plot interactively →