SPTLC1

Across TCGA cell cohorts, SPTLC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,084 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SPTLC1-associated GO terms across cancer lineages are Proteasome regulatory particle assembly, Immunoglobulin heavy chain V-D-J recombination, and Nuclear membrane organization. Each is linked with SPTLC1 in more than 14 cancer types. Because this analysis shows association rather than direction, both SPTLC1-to-partner and partner-to-SPTLC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Proteasome regulatory particle assembly grouped by SPTLC1-low versus SPTLC1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTLC1→partner) and Y-score (partner→SPTLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Proteasome regulatory particle assembly →	+0.174	+0.760	<.001	<.001	3	15
LIVER	Immunoglobulin heavy chain V-D-J recombination →	+0.184	+0.958	<.001	<.001	3	14
OVARY	Nuclear membrane organization →	+0.085	+0.722	<.001	.001	3	14
BREAST	Cellular response to environmental stimulus →	+0.042	+0.790	<.001	.002	3	12
SOFT_TISSUE	Regulation of heterochromatin organization →	+0.070	+0.465	.001	.002	3	12
BLOOD_Lymphoma	Nuclear envelope organization →	+0.073	+0.733	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,084 associations by consensus.

Proteasome regulatory particle assembly by SPTLC1 expression — OVARY

Explore this box plot interactively →