SPTBN4

Across TCGA pan-cancer cohorts, SPTBN4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SPTBN4 data layer compared with 23 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SPTBN4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SPTBN4 expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

LSCC, GBM, and HNSC are the cancer types where SPTBN4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.714	1.000	.002	31	view →
GBM	DFS	Quartile	All	0.525	0.248	.005	3	view →
HNSC	DFS	Median	III,IV	1.000	0.921	.022	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SPTBN4–LSCC (OS)

Open the LSCC breakdown →