SPTBN4

Across TCGA patient cohorts, SPTBN4 mutation is significantly associated with the RNA expression of many other genes, with 6,215 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTBN4-associated genes across cancer lineages are ADAMTSL3, SLBP, and SAAL1. Each is linked with SPTBN4 in more than 5 cancer types. Because this analysis shows association rather than direction, both SPTBN4-to-partner and partner-to-SPTBN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAMTSL3 grouped by SPTBN4-low versus SPTBN4-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTBN4→partner) and Y-score (partner→SPTBN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ADAMTSL3 →	-0.775	-2.906	.001	.001	3	6
STAD	SLBP →	+0.512	+3.355	.001	.004	3	6
UCEC	SAAL1 →	+0.429	+1.277	<.001	<.001	3	6
STAD	ADCY4 →	-0.488	-3.916	.006	<.001	3	5
STAD	RGS7BP →	-0.694	-2.873	<.001	.001	3	5
COAD	RAC3 →	+0.738	+2.920	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,215 associations by consensus.

ADAMTSL3 by SPTBN4 expression — STAD

Explore this box plot interactively →