SPTBN4

Across TCGA patient cohorts, SPTBN4 mutation is significantly associated with the total protein of many other genes, with 91 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTBN4-associated genes across cancer lineages are 4E-BP1, ASNS, and MIG-6. Each is linked with SPTBN4 in more than 5 cancer types. Because this analysis shows association rather than direction, both SPTBN4-to-partner and partner-to-SPTBN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by SPTBN4-low versus SPTBN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTBN4→partner) and Y-score (partner→SPTBN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.284	+1.478	<.001	<.001	3	6
COAD	ASNS →	+0.488	+1.882	.003	.031	3	4
COAD	MIG-6 →	+0.095	+2.644	.022	.005	3	4
BLCA	Bak →	+0.185	+2.919	.001	<.001	3	3
BLCA	Bcl-2 →	-0.161	-2.087	.014	.005	3	3
BLCA	CD31 →	-0.209	-2.567	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 91 associations by consensus.

4E-BP1 by SPTBN4 expression — UCEC

Explore this box plot interactively →