SPTBN4

Across TCGA cell cohorts, SPTBN4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,570 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPTBN4-associated GO terms across cancer lineages are Negative regulation of heart rate, Cytoskeleton-dependent intracellular transport, and Nucleoside triphosphate metabolic process. Each is linked with SPTBN4 in more than 11 cancer types. Because this analysis shows association rather than direction, both SPTBN4-to-partner and partner-to-SPTBN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of heart rate grouped by SPTBN4-low versus SPTBN4-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTBN4→partner) and Y-score (partner→SPTBN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of heart rate →	-0.176	-0.794	.002	<.001	3	12
LUNG_SCLC	Cytoskeleton-dependent intracellular transport →	+0.080	+2.330	<.001	<.001	3	12
STOMACH	Nucleoside triphosphate metabolic process →	+0.075	+1.729	.007	.009	3	12
LUNG_SCLC	Transport along microtubule →	+0.079	+2.260	<.001	<.001	3	11
BONE	Regulation of myoblast fusion →	+0.087	+1.257	<.001	.003	3	11
BONE	Regulation of base-excision repair →	+0.127	+1.575	.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,570 associations by consensus.

Negative regulation of heart rate by SPTBN4 expression — BREAST

Explore this box plot interactively →