SPTBN4

Across TCGA cell cohorts, SPTBN4 mutation is significantly associated with the RNA expression of many other genes, with 374 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPTBN4-associated genes across cancer lineages are OR56A4, VEGFA, and PAPSS2. Each is linked with SPTBN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPTBN4-to-partner and partner-to-SPTBN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56A4 grouped by SPTBN4-low versus SPTBN4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTBN4→partner) and Y-score (partner→SPTBN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR56A4 →	+0.008	+3.977	<.001	.007	3	2
LARGE_INTESTINE	VEGFA →	+1.098	+1.628	.001	.007	3	2
LARGE_INTESTINE	PAPSS2 →	+1.487	+2.000	.004	.009	3	2
LARGE_INTESTINE	NGEF →	+0.960	+2.067	.003	.004	3	2
OVARY	PPY →	+0.198	+4.029	<.001	.009	3	2
LUNG_NSCLC_LUAD	C10orf99 →	+0.100	+2.980	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 374 associations by consensus.

OR56A4 by SPTBN4 expression — SOFT_TISSUE

Explore this box plot interactively →