SPTBN2

Across TCGA patient cohorts, SPTBN2 RNA expression is significantly associated with the protein abundance of many other proteins, with 21,220 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SPTBN2-associated proteins across cancer lineages are SPTBN2_S1255, HMGB3, and ZMYM2. Each is linked with SPTBN2 in more than 5 cancer types. Because this analysis shows association rather than direction, both SPTBN2-to-partner and partner-to-SPTBN2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPTBN2 versus SPTBN2_S1255 in BRCA, with a Pearson correlation of 0.67.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTBN2→partner) and Y-score (partner→SPTBN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPTBN2_S1255 →	+1.362	+1.455	<.001	<.001	3	6
LUAD	HMGB3 →	+0.660	+0.615	.002	<.001	3	6
LSCC	ZMYM2 →	+0.269	+0.564	<.001	<.001	3	5
BRCA	VGLL4_S58 →	+0.501	+1.032	.003	<.001	3	5
GBM	SPAST →	+0.339	+1.498	<.001	<.001	3	5
BRCA	PPP1R9B →	-0.322	-1.076	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,220 associations by consensus.

SPTBN2 vs SPTBN2_S1255 — BRCA

Explore this scatter interactively →