SPTBN2

Across TCGA patient cohorts, SPTBN2 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTBN2-associated genes across cancer lineages are Rictor_pT1135, c-Myc, and PKC-a_pS657. Each is linked with SPTBN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPTBN2-to-partner and partner-to-SPTBN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by SPTBN2-low versus SPTBN2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTBN2→partner) and Y-score (partner→SPTBN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Rictor_pT1135 →	-0.258	-3.000	.001	.036	3	3
BRCA	c-Myc →	-0.347	-2.584	.011	.012	3	3
BRCA	PKC-a_pS657 →	-0.299	-2.584	.005	.012	3	3
COAD	Smad4 →	+0.107	+3.169	.026	.017	3	3
STAD	eEF2 →	+0.494	+3.000	.001	.036	3	2
STAD	NF2 →	+0.230	+3.000	.007	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Rictor_pT1135 by SPTBN2 expression — STAD

Explore this box plot interactively →