SPTBN2

Across TCGA cell cohorts, SPTBN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,909 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SPTBN2-associated GO terms across cancer lineages are Positive regulation of keratinocyte differentiation, CAAX-box protein processing, and Collagen fibril organization. Each is linked with SPTBN2 in more than 10 cancer types. Because this analysis shows association rather than direction, both SPTBN2-to-partner and partner-to-SPTBN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of keratinocyte differentiation grouped by SPTBN2-low versus SPTBN2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTBN2→partner) and Y-score (partner→SPTBN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of keratinocyte differentiation →	+0.232	+2.782	<.001	<.001	3	11
OESOPHAGUS	CAAX-box protein processing →	+0.154	+1.892	.008	<.001	2	11
BONE	Collagen fibril organization →	-0.313	-2.584	<.001	<.001	3	10
BONE	mRNA 3'-end processing →	+0.128	+3.235	<.001	<.001	3	10
BONE	Epigenetic regulation of gene expression →	+0.089	+2.917	<.001	<.001	3	10
BONE	Negative regulation of T-helper cell differentiation →	-0.196	-2.284	<.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,909 associations by consensus.

Positive regulation of keratinocyte differentiation by SPTBN2 expression — BONE

Explore this box plot interactively →