SPTBN1

Across TCGA patient cohorts, SPTBN1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,059 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SPTBN1-associated genes across cancer lineages are SEMA3G, PGM5, and JAM2. Each is linked with SPTBN1 in more than 7 cancer types. Because this analysis shows association rather than direction, both SPTBN1-to-partner and partner-to-SPTBN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPTBN1 versus SEMA3G in BRCA, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTBN1→partner) and Y-score (partner→SPTBN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SEMA3G →	+1.144	+0.345	<.001	<.001	3	8
UCEC	PGM5 →	+0.975	+0.203	.003	.004	3	8
UCEC	JAM2 →	+0.919	+0.260	<.001	<.001	3	8
UCEC	CAVIN2 →	+1.176	+0.316	<.001	<.001	3	8
GBM	FAM13C →	+0.733	+0.340	<.001	<.001	3	8
OV	C7 →	+1.883	+0.384	.004	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,059 associations by consensus.

SPTBN1 vs SEMA3G — BRCA

Explore this scatter interactively →