SPTBN1

Across TCGA patient cohorts, SPTBN1 mutation is significantly associated with the RNA expression of many other genes, with 8,357 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTBN1-associated genes across cancer lineages are KLHL17, ZNF367, and ELOCP19. Each is linked with SPTBN1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SPTBN1-to-partner and partner-to-SPTBN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL17 grouped by SPTBN1-low versus SPTBN1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTBN1→partner) and Y-score (partner→SPTBN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	KLHL17 →	+0.438	+1.947	.006	.008	3	5
STAD	ZNF367 →	+0.956	+3.807	<.001	<.001	3	5
SKCM	ELOCP19 →	+0.469	+2.143	.003	<.001	3	4
STAD	VRK1 →	+0.561	+2.717	.001	.003	3	4
LUAD	OIP5 →	+0.897	+3.807	<.001	<.001	3	4
STAD	NSD2 →	+0.581	+3.471	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,357 associations by consensus.

KLHL17 by SPTBN1 expression — COAD

Explore this box plot interactively →