SPTBN1

Across TCGA patient cohorts, SPTBN1 mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPTBN1-associated genes across cancer lineages are p70-S6K_pT389, PDCD4, and Caspase-7-cleavedD198. Each is linked with SPTBN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPTBN1-to-partner and partner-to-SPTBN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K_pT389 grouped by SPTBN1-low versus SPTBN1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTBN1→partner) and Y-score (partner→SPTBN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	p70-S6K_pT389 →	-0.219	-2.315	.045	.037	3	4
UCEC	PDCD4 →	-0.327	-1.270	.002	.002	3	4
COAD	Caspase-7-cleavedD198 →	+0.856	+1.753	.002	.047	3	4
STAD	FoxM1 →	+0.333	+3.169	.009	.019	3	3
UCEC	GAPDH →	+0.372	+1.473	.002	.004	3	3
UCEC	Tuberin →	+0.242	+1.184	<.001	.016	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

p70-S6K_pT389 by SPTBN1 expression — BRCA

Explore this box plot interactively →