SPTBN1

Across TCGA cell cohorts, SPTBN1 mutation is significantly associated with the RNA expression of many other genes, with 467 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPTBN1-associated genes across cancer lineages are ZNF232, SH3GL2, and HBZ. Each is linked with SPTBN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPTBN1-to-partner and partner-to-SPTBN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF232 grouped by SPTBN1-low versus SPTBN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPTBN1→partner) and Y-score (partner→SPTBN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF232 →	+0.699	+3.321	.001	.003	3	3
LARGE_INTESTINE	SH3GL2 →	+0.954	+2.252	.002	.004	3	3
OESOPHAGUS	HBZ →	+0.038	+2.714	.006	.007	3	2
LARGE_INTESTINE	RNF138 →	+0.648	+2.743	.003	.001	3	2
OVARY	MAMLD1 →	+1.082	+3.074	<.001	.008	2	3
OVARY	DOCK1 →	+0.815	+3.459	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 467 associations by consensus.

ZNF232 by SPTBN1 expression — LARGE_INTESTINE

Explore this box plot interactively →